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Hexarelin description 

Hexarelin (Examorelin) is a potent synthetic peptide agonist of the ghrelin receptor and growth hormone secretagoue with the amino acid sequence His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2, derived from GHRP-6. Hexarelin significantly and dose-dependently increases plasma levels of growth hormone in both animals and humans, and as with its related peptides GHRP-2 and GHRP-6, Hexarelin also slightly and, depending on the dose administered, stimulates the release of prolactin, adrenocorticotropic hormone (ACTH). ) and cortisol in humans. At the same time, Hexarelin does not affect plasma levels of glucose, luteinizing hormone (LH), follicle stimulating hormone (FSH) or thyroid stimulating hormone (TSH) in humans. 

Hexarelin releases more GH than growth hormone releasing hormone

Hexarelin releases more growth hormone than growth hormone releasing hormone (GHRH) in humans and has synergistic effects on growth hormone release in combination with GHRH, leading to a “massive” increase in plasma growth hormone levels even at low doses of Hexarelin. Clinical studies have shown that co-administration of HGH with Hexarelin suppresses the effect of Hexarelin-stimulated GH release, co-administration of IGF-1 also suppresses the effect of Hexarelin on increasing growth hormone production. Although hexarelin has achieved phase II clinical trials for the treatment of growth hormone deficiency and congestive heart failure, development has not been completed, and hexarelin has never been marketed as a treatment.

Hexarelin, anabolic steroids and muscle growth

Clinical studies have also shown that when testosterone, testosterone enanthate or ethinyl estradiol is co-administered with hexarelin, they significantly potentiate the effects of Hexarelin on growth hormone release in humans. This corresponds to the experience of experimental users who claim that large increases in muscle mass and strength can be achieved by co-administering Hexarelin with anabolic androgenic steroids and in combination with heavy strength training. At the same time, it explains why Hexarelin is often sought after by bodybuilders, powerlifters and strength athletes.

Hexarelin benefits and effects

    • Hexarelin has cardioprotective activity and helps with cardiovascular conditions such as cardiac fibrosis, ischemic heart disease, heart dysfunction or atherosclerosis
    • Hexarelin supports muscle growth and strength
    • Hexarelin has a strong anticatabolic effect
    • Hexarelin helps increase bone density
    • Hexarelin promote body fat burning

Hexarelin possible side effects

    • Irritation at the injection site
    • Carpal tunnel syndrome
    • Elevated cortisol levels
    • Elevated prolactin levels and risk of gynecomastia
    • Decreased insulin sensitivity
    • Water retention

Hexarelin dosage

In the scientific studies optimal dose of Hexarelin is often reported as 1 mcg of Hexarelin per 1 kg body weight 3 times daily.

Long-term administration of hexarelin results in a partial and reversible tolerance to the growth hormone releasing effects of hexarelin (a 50-75% decrease in efficacy over weeks to months of hexarelin use).


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