Ibutamoren MK-677


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Ibutamoren MK-677 Description

Ibutamoren MK-677 (Ibutamoren Mesylate, MK-0677, L-163,191) is a non-peptide, potent and long-acting a selective agonist of ghrelin-binding receptors . Ibutamoren is a powerful tablet stimulant of self-production growth hormone (endogenous GH) and a strongly anabolic hormone IGF-1 in body. Athletes are looking for Ibutamoren mainly for its excellent ability to help build new muscle gains (achieve a positive nitrogen balance) and strong anti-catabolic effects – the ability to maintain and protect muscle mass from breakdown, degradation, catabolism.

Chemical structure of Ibutamoren MK-677

Ibutamoren and growth hormone (GH)

Ibutamoren is a strong and long-acting selective ghrelin receptor agonist . Ghrelin receptors – GHSRs (Growth hormone secretagogue receptors) naturally trigger the production of endogenous growth hormone . Ibutamoren stimulates the production of growth hormone essentially by mimicking the function and activity of another endogenous hormone – ghrelin: The action and binding of Ibutamorene MK-677 to Ghrelin receptors first results in the release GHRH (Growth-hormone-releasing hormone) from neurons in the Nucleus arcuatus (infundibular nucleus of the Hypothalamus), which is then transmitted by the hypothalamic-pituitary portal system to the anterior Pituitary, where by acting on GHRHR (Growth hormone-releasing hormone receptor (GHRH receptors)) stimulates the resulting growth hormone secretion pituitary gland.

Ibutamoren stimulates HGH production in all ways

Ibutamoren However, MK-677 can not only effectively stimulate HGH production by imitating ghrelin activity and acting on Ghrelin receptors, but also potentiates GHRH signaling (growth hormone releasing hormone) in the GHRHR (growth hormone releasing hormone receptors) of the anterior pituitary gland, reduces the release somatostatin (an undesirable hormone that blocks the release of GH) and at the same time inhibits the signaling of somatostatin receptors. Ibutamoren stimulates the production of growth hormone in all the possible ways known so far, thanks to which it is one of the most effective, strongest and most effective stimulants of HGH, the production of natural growth hormone in the body at all.

Ibutamoren, clinical trials, IGF-1

Clinical trials have shown that Ibutamoren MK-677 is even more effective than GHRH alone in healthy adult men: After taking a 1 daily dose of Ibutamoren 25 mg, the maximum HGH concentration up to 22.1 micrograms per milliliter. After 7 days of taking this dose, test subjects showed a sustained increase in levels and IGF-1 concentration, and despite being on a strict diet that would cause a placebo negative nitrogen balance (catabolic state – loss of muscle mass), this condition was reversed with Ibutamoren and on the contrary achieved a positive nitrogen balance (anabolic state), which confirmed high efficiency and the excellent ability of Ibutamoren MK-677 to build new muscle growth. Ibutamoren has been found to increase permanently and for a long time IGF-1 level in the blood by 40-90% for the entire period of its use. Studies in the treatment of osteoporosis, in turn, showed that the use of Ibutamoren increased bone mineral density, confirming its positive effect on bone density. Ibutamoren is also thought to strengthen the body’s immune system and resistance.

Increased production of endogenous HGH

As a result taking Ibutamoren MK-677 is sharp increase in HGH production , which subsequently results in a significant and permanent increase in the strongly anabolic the hormone IGF-1 and nitrogen retention in the body (anabolic state). Increase in natural levels HGH and IGF-1 has countless benefits for the body and overall health. Ibutamoren strongly supports the growth of muscle mass, improved performance and condition, fat burning, better and faster regeneration, quality sleep (sleep usually improves after a few days of use), improved skin condition and quality, increases bone density, helps heal old wounds, brings a very strong sense of energy and vitality, and has a strong anti-catabolic and antiaging (rejuvenating) effect.

Ibutamoren and cortisol

Another valuable feature of the MK-677 is the fact that even its long-term use does not cause a simultaneous increase in production and levels Cortisol (an unwanted, stressful, and very strongly catabolic hormone). Ibutamoren MK-677 is a great way to easily, very effectively and painlessly increase natural levels of HGH and IGF-1 , and take advantage of all the benefits that come with it.


    • Ibutamoren MK-677 strongly supports the growth of muscle mass and anabolic state of the body (helps maintain a positive nitrogen balance)
    • Ibutamoren MK-677 has a strong anti-catabolic effect, effectively protects muscle mass from degradation
    • Ibutamoren MK-677 improves performance and condition
    • Ibutamoren MK-677 speeds up fat metabolism – helps burn excess body fat and prevent its re-storage
    • Ibutamoren MK-677 brings very good and faster regeneration of muscles and the whole body, helps to heal old wounds and injuries
    • Ibutamoren MK-677 significantly improves sleep quality at night, brings a very strong feeling of freshness, energy and vitality in the morning and during the day
    • Ibutamoren MK-677 leads to a significant improvement in the condition and quality of the skin, helps to smooth out wrinkles
    • Ibutamoren MK-677 has a strong anti-aging effect, rejuvenates the body, acts against aging

Ibutamoren and possible side effects

Ibutamoren MK-677 is a very organism well tolerated and does not present any significant or dangerous side and side effects for him. Medical studies have shown that this is very safe HGH stimulant , and laboratory tests have even shown that its use has reduced the incidence of tumors in mice, which scientists believe is due to an increased immune response – thanks to using MK-677 . However, sensitive individuals may experience some mild side effects (especially at higher doses):

    • Solidification of the limbs or swelling of the fingertips
    • Irrigation (water retention)
    • Lethargy
    • Gradually increasing hunger
    • Decreased insulin sensitivity
    • Slight increase in prolactin production (possibly in people extremely hypersensitive to prolactin, there is a possible risk of gynecomastia, which, however, represents only about 1% of men)


Optimal dose of Ibutamoren is 25-50 mg daily (1-2 tablets), max. 75 mg (max. 3 tablets a day, higher doses no longer represent a significant or linear increase in effects, but on the contrary – they can bring side effects). The usual period of use is 12 weeks. However, even with a long-term daily use of Ibutamoren No significant or dangerous side effects have been reported in medical studies for 12 or up to 24 months.


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