SR9009 Stenabolic description
Metabolic modulator SR9009 Stenabolic is a research compound developed by Professor Thomas Burris of the Scripps Research Institute. SR9009 is REV-ERB agonist , which increases the constitutive repression of genes regulated by REV-ERB and has good bioavailability. It is a synthetic substance created for study circadian rhythm . Showed that SR9009 reduces fat storage , further lowers cholesterol levels and inflammation in mice, and increases endurance. However, Stenabolic has not been clinically tested in humans.
SR9009, weight loss, fat burning
Overall, Stenabolic is proving to be useful for people who want to lose weight or increase performance and endurance: SR9009 supports reduced production of new fat cells, cholesterol and bile acids in the liver, increased use of glucose and fatty acids in muscles and reduced fat storage, helps burn fat, improves overall metabolism, lowers triglycerides and total cholesterol in the blood, increases endurance, endurance and performance.
How SR9009 Stenabolic works
Effects of SR9009 result from activation of REV-ERB proteins (NR1D1, NR1D2) in the body. REV-ERB are a pair of proteins that stabilize ours internal clock (circadian rhythm) by turning off BMAL1. REV-ERB occurs mainly in the liver, muscles and adipose tissue. In addition to its effect on circadian rhythm (suppression of BMAL1 production), REV-ERB affects many other functions related to energy production.
In the liver, REV-ERB shuts down glucose-producing genes without altering insulin sensitivity. It also turns on genes that generate new fat cells and reduce the inflammatory response (by affecting the production of macrophages).
Activating REV-ERB-α with the SR9009 increases performance capacity by increasing the number mitochondria in skeletal muscle: REV-ERB increases mitochondrial activity in muscles (by suppressing autophagic genes) and promotes the formation of new and at the same time reduces the destruction of old mitochondria, and also promotes fat burning.
In fat cells, REV-ERB shuts down the genes responsible for storing fat and reduces the production of triglycerides .
BMAL1 (Brain and Muscle ARNT-Like 1)
BMAL1 (Brain and Muscle ARNT-Like 1) is a protein that is encoded by the Bmal1 gene in humans. It is a 626 amino acid protein and plays a key role as one of the positive elements in the mammalian autoregulatory loop of negative transcription and translation feedback (TTFL), which is responsible for generating molecular circadian rhythms .
Research has shown that Bmal1 is the only clock gene without which the circadian clock does not work in humans. Bmal1 has also been identified as a candidate gene for susceptibility to hypertension, diabetes and obesity, and mutations in Bmal1 have been associated with infertility, problems with gluconeogenesis and lipogenesis, and changes in sleep patterns. BMAL1 is estimated to be more than 150 sites in the human genome based on whole genome profiling, including all clock genes and genes encoding proteins that regulate metabolism .
Results of research studies with SR9009
In animal and cell studies, SR9009 Stenabolic caused:
- Increased oxygen consumption
- Reduced production of new fat cells in the liver
- Reduced production of cholesterol and bile acids in the liver
- Increased the number of mitochondria in the muscles
- Increased use of glucose and fatty acids in muscles
- Reduced fat storage
SR9009 BENEFITS AND EFFECTS
- SR9009 effectively helps burn fat
- SR9009 improves overall metabolism – glucose and calorie metabolism
- SR9009 improves basal metabolism
- SR9009 lowers blood triglycerides and total cholesterol
- SR9009 increases endurance, endurance and performance
- SR9009 can potentially help maintain alertness
- SR9009 reduces liver tissue damage
Side effects SR9009
Side effects SR9009 are not known because its safety profile has not been investigated. To date, no scientific studies have been published on the use of SR9009 in humans. SR9009 has not yet shown any hepatic toxicity in mice when used for up to 7 weeks. SR9009 is not hormonally estrogenic or androgenic. Some of the side effects reported by SR9009 are:
- Stomach upset (especially in people with indigestion)
- Mild cramps, diarrhea and constipation (use with food may prevent this)
- Insomnia or difficulty falling asleep (to prevent this, do not take the dose in the evening)
To date, none have been scientifically established dose of Stenabolic for the human. Most experiments on mice used a dose of 100 mg / kg administered intraperitoneally. However, online bodybuilding forums suggest much lower daily dose SR9009 10-30 mg and its division into 2-4 doses per day.